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p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr"))

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Entity

Name
Tau isoform F (441 aa)
Namespace
HBP
Namespace Version
20190207
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/cf4d8bb88754f036b943b4d94ad96e103dcb7149/export/hbp-names.belns

Appears in Networks 1

Caenorhabditis elegans models of tauopathy v1.0.0

In-Edges 2

bp(GO:"cell aging") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) View Subject | View Object

Thus, TauA152T affects both neuronal aging and whole organism lifespan PubMed:29191965

Appears in Networks:
Annotations
MeSH
Neurons

p(HBP:"Tau isoform F (441 aa)") hasVariant p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) View Subject | View Object

Appears in Networks:

Out-Edges 5

p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) increases path(MESH:Paralysis) View Subject | View Object

Although the wild-type tau lines showed a mild late-onset dose-dependent Unc phenotype, TauA152T worms showed early-onset paralysis and acute neuronal dysfunction. PubMed:29191965

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases act(a(MESH:Neurons)) View Subject | View Object

Although the wild-type tau lines showed a mild late-onset dose-dependent Unc phenotype, TauA152T worms showed early-onset paralysis and acute neuronal dysfunction. PubMed:29191965

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) negativeCorrelation bp(GO:"cell aging") View Subject | View Object

Thus, TauA152T affects both neuronal aging and whole organism lifespan PubMed:29191965

Appears in Networks:
Annotations
MeSH
Neurons

p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases bp(MESH:Longevity) View Subject | View Object

Thus, TauA152T affects both neuronal aging and whole organism lifespan PubMed:29191965

Appears in Networks:
Annotations
MeSH
Neurons

p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases bp(GO:"anterograde axonal transport of mitochondrion") View Subject | View Object

Comparison of the mitochondrial transport in the wildtype tau and TauA152T lines revealed striking differences; wild-type tau lines showed a late onset akin to both antero- and retrograde mitochondrial transport defects, whereas TauA152T lines showed mainly early-onset anterograde mitochondrial transport defects PubMed:29191965

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.