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rxn(reactants(a(CHEBI:arginine)), products(a(CHEBI:ornithine)))

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Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 1

a(MESH:Arginase) positiveCorrelation rxn(reactants(a(CHEBI:arginine)), products(a(CHEBI:ornithine))) View Subject | View Object

In addition, lysed erythrocytes release arginase, which catalyzes the conversion of arginine, the substrate for NO synthesis, to ornithine. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

Out-Edges 4

rxn(reactants(a(CHEBI:arginine)), products(a(CHEBI:ornithine))) hasReactant a(CHEBI:arginine) View Subject | View Object

Appears in Networks:

rxn(reactants(a(CHEBI:arginine)), products(a(CHEBI:ornithine))) hasProduct a(CHEBI:ornithine) View Subject | View Object

Appears in Networks:

rxn(reactants(a(CHEBI:arginine)), products(a(CHEBI:ornithine))) positiveCorrelation a(MESH:Arginase) View Subject | View Object

In addition, lysed erythrocytes release arginase, which catalyzes the conversion of arginine, the substrate for NO synthesis, to ornithine. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

rxn(reactants(a(CHEBI:arginine)), products(a(CHEBI:ornithine))) decreases a(CHEBI:"nitric oxide") View Subject | View Object

Both processes decrease the availability of NO, which normally maintains smooth muscle cell relaxation, inhibits platelet activation and aggregation, and has anti-inflammatory effects on the endothelium. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.