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path(HBP:"isolation rearing")

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Entity

Name
isolation rearing
Namespace
HBP
Namespace Version
20190207
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/cf4d8bb88754f036b943b4d94ad96e103dcb7149/export/hbp-names.belns

Appears in Networks 1

The CRF1 receptor antagonist, antalarmin, reverses isolation-induced up-regulation of dopamine D2 receptors in the amygdala and nucleus accumbens of fawn-hooded rats v1.0.0

In-Edges 3

a(MESH:antalarmin) decreases path(HBP:"isolation rearing") View Subject | View Object

Furthermore a significant interaction was found between housing and treatment in both the central nucleus of the amygdala (CeA; F1,139 1⁄4 11.560, P < 0.001; Fig. 3F) and basolateral amygdala (BLA; F1,137 1⁄4 7.616, P 1⁄4 0.007; Fig. 3E).Thus, isolation caused an up-regulation in dopamine D2 ⁄ 3 receptors in these regions, an effect that was reversed by antalarmin treatment (but only reached statistical significance in the CeA). PubMed:16820021

Appears in Networks:
Annotations
MeSH
Nucleus Accumbens

a(MESH:antalarmin) causesNoChange path(HBP:"isolation rearing") View Subject | View Object

Treatment with antalarmin had no impact upon the isolation-induced alterations of BDNF expression. PubMed:16820021

Appears in Networks:
Annotations
MeSH
Basolateral Nuclear Complex
MeSH
Dentate Gyrus
MeSH
Diagonal Band of Broca

a(MESH:antalarmin) causesNoChange path(HBP:"isolation rearing") View Subject | View Object

As was the case with BDNF expression, treatment with antalarmin had no impact upon the isolation-induced alterations in TrkB expression. PubMed:16820021

Appears in Networks:
Annotations
MeSH
Dentate Gyrus
MeSH
Hippocampus

Out-Edges 8

path(HBP:"isolation rearing") increases p(RGD:Drd2) View Subject | View Object

Isolation rearing caused an up-regulation of dopamine D2 ⁄ 3 receptors in both the core (+20%; F1,144 1⁄4 31.176, P < 0.001; Fig. 3A) and shell (+25%; F1,148 1⁄4 35.233, P < 0.001; Fig. 3B) of the NAcc. PubMed:16820021

Appears in Networks:
Annotations
MeSH
Nucleus Accumbens

path(HBP:"isolation rearing") increases p(RGD:Drd2) View Subject | View Object

Furthermore a significant interaction was found between housing and treatment in both the central nucleus of the amygdala (CeA; F1,139 1⁄4 11.560, P < 0.001; Fig. 3F) and basolateral amygdala (BLA; F1,137 1⁄4 7.616, P 1⁄4 0.007; Fig. 3E).Thus, isolation caused an up-regulation in dopamine D2 ⁄ 3 receptors in these regions, an effect that was reversed by antalarmin treatment (but only reached statistical significance in the CeA). PubMed:16820021

Appears in Networks:
Annotations
MeSH
Nucleus Accumbens

path(HBP:"isolation rearing") increases p(RGD:Drd3) View Subject | View Object

Isolation rearing caused an up-regulation of dopamine D2 ⁄ 3 receptors in both the core (+20%; F1,144 1⁄4 31.176, P < 0.001; Fig. 3A) and shell (+25%; F1,148 1⁄4 35.233, P < 0.001; Fig. 3B) of the NAcc. PubMed:16820021

Appears in Networks:
Annotations
MeSH
Nucleus Accumbens

path(HBP:"isolation rearing") increases p(RGD:Drd3) View Subject | View Object

Furthermore a significant interaction was found between housing and treatment in both the central nucleus of the amygdala (CeA; F1,139 1⁄4 11.560, P < 0.001; Fig. 3F) and basolateral amygdala (BLA; F1,137 1⁄4 7.616, P 1⁄4 0.007; Fig. 3E).Thus, isolation caused an up-regulation in dopamine D2 ⁄ 3 receptors in these regions, an effect that was reversed by antalarmin treatment (but only reached statistical significance in the CeA). PubMed:16820021

Appears in Networks:
Annotations
MeSH
Nucleus Accumbens

path(HBP:"isolation rearing") decreases r(RGD:Bdnf) View Subject | View Object

A significant decrease in BDNF mRNA expression resulting from ISO was found in the BLA ()25%; F1,102 1⁄4 77.937, P < 0.001), nucleus of the horizontal limb of the diagonal band (HB )75%; F1,67 1⁄4 259.106, P < 0.001) and dentate gyrus (DG )85%; F1,101 1⁄4 984.958, PubMed:16820021

Appears in Networks:
Annotations
MeSH
Basolateral Nuclear Complex
MeSH
Dentate Gyrus
MeSH
Diagonal Band of Broca

path(HBP:"isolation rearing") increases r(RGD:Bdnf) View Subject | View Object

whilst isolation increased BDNF mRNA expression in the retrosplenial cortex PubMed:16820021

Appears in Networks:
Annotations
MeSH
Basolateral Nuclear Complex
MeSH
Dentate Gyrus
MeSH
Diagonal Band of Broca

path(HBP:"isolation rearing") decreases r(RGD:Ntrk2) View Subject | View Object

ISO resulted in a decrease in TrkB mRNA expression in the cingulate cortex (Cg1–3; F1,124 1⁄4 7.582, P 1⁄4 0.014) and piriform cortex (Pir; F1,119 1⁄4 3.869 PubMed:16820021

Appears in Networks:
Annotations
MeSH
Gyrus Cinguli
MeSH
Piriform Cortex

path(HBP:"isolation rearing") increases r(RGD:Ntrk2) View Subject | View Object

whereas an increase was observed in isolates compared to GH in the hippocampus (+38%; F1,59 1⁄4 14.131, P < 0.001), DG (+32%; F1,56 1⁄4 8.398, P 1⁄4 0.005) and RSc (+32%; F1,56 1⁄4 6.830, P 1⁄4 0.011). PubMed:16820021

Appears in Networks:
Annotations
MeSH
Dentate Gyrus
MeSH
Hippocampus

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.