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a(CHEBI:"L-dopa")

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Entity

Name
L-dopa
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 2

a(CHEBI:"folate(2-)") negativeCorrelation act(a(CHEBI:"L-dopa")) View Subject | View Object

Folate starvation in the presence of L-dopa resulted in a 200–210% increase in demethylated PP2A levels, and 235–250% increase in p-Tau levels in the dopaminergic neurons, relative to untreated controls maintained in NF medium. PubMed:22764226

Appears in Networks:
Annotations
Uberon
dopaminergic cell groups

a(CHEBI:"folate(2-)") negativeCorrelation act(a(CHEBI:"L-dopa")) View Subject | View Object

Here, we found that administration of L-dopa led to a significant 5-fold increase in plasma tHcy concentrations, when compared to saline treated mice (Table 1). This L-dopa induced increase in plasma tHcy was significantly greater in mice that had been reared on either low folate (LF) or FD diets (Table 1). PubMed:22764226

Appears in Networks:
Annotations
Uberon
blood plasma

Out-Edges 7

act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me)) View Subject | View Object

Incubation of human SH-SY5Y neuroblastoma cells for 2 h with L-dopa induced a dose-dependent decrease in both soluble and insoluble methylated PP2A C subunit levels, and concomitant accumulation of demethylated PP2A enzymes PubMed:22764226

Appears in Networks:

act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me)) View Subject | View Object

Significantly, we found similar effects in human dopaminergic neurons (Fig. 2F). Treatment of neurons with L-Dopa induced a 40–49% decrease in methylated PP2A and concomitant 168–179% increase in endogenous p-Tau (PHF-1) levels (Fig. 2G). PubMed:22764226

Appears in Networks:
Annotations
Uberon
dopaminergic cell groups

act(a(CHEBI:"L-dopa")) increases a(HBP:"Tau epitope, PHF1") View Subject | View Object

Significantly, we found similar effects in human dopaminergic neurons (Fig. 2F). Treatment of neurons with L-Dopa induced a 40–49% decrease in methylated PP2A and concomitant 168–179% increase in endogenous p-Tau (PHF-1) levels (Fig. 2G). PubMed:22764226

Appears in Networks:
Annotations
Uberon
dopaminergic cell groups

act(a(CHEBI:"L-dopa")) negativeCorrelation a(CHEBI:"folate(2-)") View Subject | View Object

Folate starvation in the presence of L-dopa resulted in a 200–210% increase in demethylated PP2A levels, and 235–250% increase in p-Tau levels in the dopaminergic neurons, relative to untreated controls maintained in NF medium. PubMed:22764226

Appears in Networks:
Annotations
Uberon
dopaminergic cell groups

act(a(CHEBI:"L-dopa")) negativeCorrelation a(CHEBI:"folate(2-)") View Subject | View Object

Here, we found that administration of L-dopa led to a significant 5-fold increase in plasma tHcy concentrations, when compared to saline treated mice (Table 1). This L-dopa induced increase in plasma tHcy was significantly greater in mice that had been reared on either low folate (LF) or FD diets (Table 1). PubMed:22764226

Appears in Networks:
Annotations
Uberon
blood plasma

act(a(CHEBI:"L-dopa")) increases a(CHEBI:homocysteine) View Subject | View Object

Here, we found that administration of L-dopa led to a significant 5-fold increase in plasma tHcy concentrations, when compared to saline treated mice (Table 1). This L-dopa induced increase in plasma tHcy was significantly greater in mice that had been reared on either low folate (LF) or FD diets (Table 1). PubMed:22764226

Appears in Networks:
Annotations
Uberon
blood plasma

act(a(CHEBI:"L-dopa")) decreases p(MGI:Ppp2ca, pmod(Me)) View Subject | View Object

Reductions in PP2A methylation were associated with a concomitant increase in each brain region of p-Tau at the PHF-1 epitope (Fig. 6A,B). PubMed:22764226

Appears in Networks:
Annotations
Uberon
blood plasma

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.