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g(HGNC:MIR132)

Orthologies: 0 | Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
MIR132
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Tau in physiology and pathology v1.0.0

New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases v1.0.0

In-Edges 3

path(MESH:"Supranuclear Palsy, Progressive") negativeCorrelation g(HGNC:MIR132) View Subject | View Object

For instance, miR‑132, which is downregulated in PSP, reduces 4R tau expression in mouse neuroblastoma cells. PubMed:26631930

Appears in Networks:

p(HGNC:NR4A2) association g(HGNC:MIR132) View Subject | View Object

In fact, by directly affecting the expression of Nurr1, this miRNA can play a significant role in the development of PD PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

path(MESH:"Parkinson Disease") association g(HGNC:MIR132) View Subject | View Object

However, this is part of the role that miR‐132 plays in the regulation of PD. PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

Out-Edges 8

g(HGNC:MIR132) negativeCorrelation path(MESH:"Supranuclear Palsy, Progressive") View Subject | View Object

For instance, miR‑132, which is downregulated in PSP, reduces 4R tau expression in mouse neuroblastoma cells. PubMed:26631930

Appears in Networks:

g(HGNC:MIR132) decreases p(HBP:"4R tau") View Subject | View Object

For instance, miR‑132, which is downregulated in PSP, reduces 4R tau expression in mouse neuroblastoma cells. PubMed:26631930

Appears in Networks:

g(HGNC:MIR132) regulates p(HGNC:SNCA) View Subject | View Object

miR‐132 is another miRNA that has a regulatory effect on α‐synuclein. The downregulation of this miRNA results in the accumulation of α‐synuclein protein PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

g(HGNC:MIR132) decreases p(HGNC:SNCA) View Subject | View Object

miR‐132 is another miRNA that has a regulatory effect on α‐synuclein. The downregulation of this miRNA results in the accumulation of α‐synuclein protein PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

g(HGNC:MIR132) regulates p(HGNC:SNCA) View Subject | View Object

That is, in the event that miRNAs regulating α‐synuclein that reduce its accumulation (including miR‐153, miR‐7, miR‐132, and miR‐133‐b) are decreased, the progression of PD will be accelerated. PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

g(HGNC:MIR132) association path(MESH:"Parkinson Disease") View Subject | View Object

However, this is part of the role that miR‐132 plays in the regulation of PD. PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

g(HGNC:MIR132) decreases path(MESH:"Parkinson Disease") View Subject | View Object

That is, in the event that miRNAs regulating α‐synuclein that reduce its accumulation (including miR‐153, miR‐7, miR‐132, and miR‐133‐b) are decreased, the progression of PD will be accelerated. PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

g(HGNC:MIR132) association p(HGNC:NR4A2) View Subject | View Object

In fact, by directly affecting the expression of Nurr1, this miRNA can play a significant role in the development of PD PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.