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a(PUBCHEM:10013505)

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Entity

Name
10013505
Namespace
PUBCHEM
Namespace Version
None
Pattern
^\d+$

Appears in Networks 1

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

In-Edges 0

Out-Edges 5

a(PUBCHEM:10013505) increases act(p(HGNC:CHRM1)) View Subject | View Object

Moreover, the M1 agonist AF267B can rescue the cognitive impairment and decrease Aβ42 and tau abnormalities in the cortex and hippocampus of a mouse model of AD PubMed:26813123

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Neocortex
MeSH
Alzheimer Disease

a(PUBCHEM:10013505) increases bp(GO:cognition) View Subject | View Object

Moreover, the M1 agonist AF267B can rescue the cognitive impairment and decrease Aβ42 and tau abnormalities in the cortex and hippocampus of a mouse model of AD PubMed:26813123

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Neocortex
MeSH
Alzheimer Disease

a(PUBCHEM:10013505) decreases a(CHEBI:"amyloid-beta polypeptide 42") View Subject | View Object

Moreover, the M1 agonist AF267B can rescue the cognitive impairment and decrease Aβ42 and tau abnormalities in the cortex and hippocampus of a mouse model of AD PubMed:26813123

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Neocortex
MeSH
Alzheimer Disease

a(PUBCHEM:10013505) decreases p(HGNC:MAPT, var("?")) View Subject | View Object

Moreover, the M1 agonist AF267B can rescue the cognitive impairment and decrease Aβ42 and tau abnormalities in the cortex and hippocampus of a mouse model of AD PubMed:26813123

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Neocortex
MeSH
Alzheimer Disease

a(PUBCHEM:10013505) increases a(MESH:"Amyloid Precursor Protein Secretases") View Subject | View Object

Moreover, AF267B treatment leads to an increase in alpha secretase, which is an enzyme that can prevent the production of Aβ peptide PubMed:26813123

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.