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a(HP:"inhibitory interneuron")

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Entity

Name
inhibitory interneuron
Namespace
HP
Namespace Version
2017-10-05
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/hp/hp-20171108.belns

Appears in Networks 1

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0

In-Edges 4

a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association a(HP:"inhibitory interneuron") View Subject | View Object

Although alpha7 nAChRs have both presynaptic and postsynaptic expression (Frazier et al., 1998), their postsynaptic expression in humans is especially marked on inhibitory neurons of the hippocampus (Alkondon et al., 2000) PubMed:21482353

Appears in Networks:
Annotations
MeSH
Hippocampus

a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases a(HP:"inhibitory interneuron") View Subject | View Object

First, postmortem studies of the hippocampus and thalamus show diminished labeling of putative inhibitory neurons by alpha-bungarotoxin, an antagonist of alpha7 nAChRs (Court et al., 1999) PubMed:21482353

Appears in Networks:
Annotations
MeSH
Schizophrenia

p(FPLX:CHRN) increases act(a(HP:"inhibitory interneuron")) View Subject | View Object

Nicotinic activation of inhibitory interneurons increases their activity and activates nitric oxide synthetase PubMed:21482353

Appears in Networks:

g(HGNC:CHRFAM7A, var("?")) negativeCorrelation act(a(HP:"inhibitory interneuron")) View Subject | View Object

Polymorphisms in the alpha7 5' promoter and in a nearby partial duplication of the gene, FAM7A, are associated with both schizophrenia and the defect in inhibition (Leonard et al., 2002) PubMed:21482353

Appears in Networks:
Annotations
MeSH
Schizophrenia

Out-Edges 4

a(HP:"inhibitory interneuron") regulates bp(GO:"sensory processing") View Subject | View Object

alpha7 nAChRs on inhibitory interneurons throughout the hippocampus and presynaptic alpha7 nAChRs on mossy fiber terminals in the dentate gyrus participate in the control of sensory response in the hippocampus (Gray et al., 1996; Alkondon et al., 1999 PubMed:21482353

Appears in Networks:
Annotations
MeSH
Dentate Gyrus
MeSH
Hippocampus

act(a(HP:"inhibitory interneuron")) increases act(p(FPLX:NOS)) View Subject | View Object

Nicotinic activation of inhibitory interneurons increases their activity and activates nitric oxide synthetase PubMed:21482353

Appears in Networks:

a(HP:"inhibitory interneuron") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") View Subject | View Object

Although alpha7 nAChRs have both presynaptic and postsynaptic expression (Frazier et al., 1998), their postsynaptic expression in humans is especially marked on inhibitory neurons of the hippocampus (Alkondon et al., 2000) PubMed:21482353

Appears in Networks:
Annotations
MeSH
Hippocampus

act(a(HP:"inhibitory interneuron")) negativeCorrelation g(HGNC:CHRFAM7A, var("?")) View Subject | View Object

Polymorphisms in the alpha7 5' promoter and in a nearby partial duplication of the gene, FAM7A, are associated with both schizophrenia and the defect in inhibition (Leonard et al., 2002) PubMed:21482353

Appears in Networks:
Annotations
MeSH
Schizophrenia

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.