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a(MESH:Fibrin)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Fibrin
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

a(CHEBI:heme) decreases a(MESH:Fibrin) View Subject | View Object

From another perspective, in vitro assays have demonstrated that heme can also bind to fibrinogen and decrease its thrombin-mediated cleavage, thus affecting the final common coagulation pathway and reducing fibrin formation, important in clotting [44] (Figure 1). PubMed:26875449

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Review

a(CHEBI:heme) decreases a(MESH:Fibrin) View Subject | View Object

Heme perturbs the enzymatic activity of thrombin, further contributing to the overall anticoagulant effect and decreased fibrin formation [45]. PubMed:26875449

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Review

a(CHEBI:heme) decreases a(MESH:Fibrin) View Subject | View Object

Taken sequentially, it appears that the release of heme under hemolytic conditions initiates the extrinsic pathway of coagulation through the upregulation of TF on endothelial cells and leukocytes, but subsequently blocks the propagation of coagulation by inhibiting FVIII and FV, and by inhibiting the conversion of fibrinogen into fibrin and fibrin clots. PubMed:26875449

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Review

a(HM:schistocytes) positiveCorrelation a(MESH:Fibrin) View Subject | View Object

During DIC, fibrin strands within the fibrin mesh formed could cut red blood cells, resulting in the formation of schistocytes (strongly deformed red blood cells or fragments of red blood cells) and the release of hemoglobin. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Disseminated Intravascular Coagulation
Text Location
Review

p(HGNC:HBB) positiveCorrelation a(MESH:Fibrin) View Subject | View Object

During DIC, fibrin strands within the fibrin mesh formed could cut red blood cells, resulting in the formation of schistocytes (strongly deformed red blood cells or fragments of red blood cells) and the release of hemoglobin. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Disseminated Intravascular Coagulation
Text Location
Review

Out-Edges 2

a(MESH:Fibrin) positiveCorrelation a(HM:schistocytes) View Subject | View Object

During DIC, fibrin strands within the fibrin mesh formed could cut red blood cells, resulting in the formation of schistocytes (strongly deformed red blood cells or fragments of red blood cells) and the release of hemoglobin. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Disseminated Intravascular Coagulation
Text Location
Review

a(MESH:Fibrin) positiveCorrelation p(HGNC:HBB) View Subject | View Object

During DIC, fibrin strands within the fibrin mesh formed could cut red blood cells, resulting in the formation of schistocytes (strongly deformed red blood cells or fragments of red blood cells) and the release of hemoglobin. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Disseminated Intravascular Coagulation
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.