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complex(p(HGNC:PLD1), p(HGNC:PSEN1))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 1

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

In-Edges 0

Out-Edges 3

complex(p(HGNC:PLD1), p(HGNC:PSEN1)) hasComponent p(HGNC:PLD1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:PLD1), p(HGNC:PSEN1)) hasComponent p(HGNC:PSEN1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:PLD1), p(HGNC:PSEN1)) increases p(HGNC:APP) View Subject | View Object

This PS1-PLD1 interaction recruits PLD1 to the Golgi/TGN and thus potentially alters APP trafficking as PLD1 overexpression promotes budding of vesicles from the TGN containing APP and increases cell surface levels of APP [176,177] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.