complex(p(HGNC:PLD1), p(HGNC:PSEN1)) increases p(HGNC:APP)

PubMed:21214928

This PS1-PLD1 interaction recruits PLD1 to the Golgi/TGN and thus potentially alters APP trafficking as PLD1 overexpression promotes budding of vesicles from the TGN containing APP and increases cell surface levels of APP [176,177]

MeSH

Endosomes

Confidence

High

MeSH

Hippocampus

MeSH

Down Syndrome

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.