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  3. complex(p(HGNC:PPME1), p(HGNC:PPP2CA))

complex(p(HGNC:PPME1), p(HGNC:PPP2CA))

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Components

Appears in Networks 1

Protein phosphatase 2A dysfunction in Alzheimer’s disease v1.0.0

In-Edges 1

p(HGNC:PPME1) increases complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) View Subject | View Object

Conversely, the PP2A-specific methylesterase PME-1 can directly bind to the active site of the catalytic subunit, remove the methyl group and inactivate PP2A by evicting manganese ions required for phosphatase activity (Xing et al.,2008). PubMed:24653673

Appears in Networks:

Out-Edges 4

complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) hasComponent p(HGNC:PPME1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) hasComponent p(HGNC:PPP2CA) View Subject | View Object

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complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) View Subject | View Object

Conversely, the PP2A-specific methylesterase PME-1 can directly bind to the active site of the catalytic subunit, remove the methyl group and inactivate PP2A by evicting manganese ions required for phosphatase activity (Xing et al.,2008). PubMed:24653673

Appears in Networks:

complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") View Subject | View Object

Furthermore, direct interaction of PP2A catalytic subunit with specific regulatory proteins, including PME-1, LCMT1, the alpha4 subunit, and the PP2A phosphatase activator PTPA, critically modulates PP2A biogenesis and stability PubMed:24653673

Appears in Networks:

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.