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p(HGNC:ATXN3)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
ATXN3
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 5

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

The Biology of Proteostasis in Aging and Disease v1.0.0

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. v1.0.0

Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity v1.0.0

In-Edges 2

complex(p(HGNC:ATXN3), p(HGNC:RAD23A)) hasComponent p(HGNC:ATXN3) View Subject | View Object

Appears in Networks:

a(PUBCHEM:675434) decreases p(HGNC:ATXN3) View Subject | View Object

Treatment with IU1 reduced the levels of Tau, TDP-43, and ataxin-3 in MEFs in a USP14-dependent manner and independently of changes in proteasome levels or composition (147). PubMed:25784053

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
MEF cell line
Cell Ontology (CL)
motor neuron

Out-Edges 4

p(HGNC:ATXN3) hasVariant p(HGNC:ATXN3, frag("?")) View Subject | View Object

Appears in Networks:

p(HGNC:ATXN3) hasVariant p(HGNC:ATXN3, pmod(Ub)) View Subject | View Object

Appears in Networks:

p(HGNC:ATXN3) increases complex(p(HGNC:ATXN3), p(HGNC:RAD23A)) View Subject | View Object

It interacts with the human homolog of Rad23, a cytosolic protein that binds polyubiquitinated proteins and is involved, most probably, in shuttling them to the proteasome. PubMed:14556719

Appears in Networks:

p(HGNC:ATXN3) hasVariant p(HGNC:ATXN3, var("?")) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.