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complex(p(HGNC:APP), p(HGNC:APP))

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Components

Appears in Networks 1

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

In-Edges 2

a(HBP:HBP00078) increases complex(p(HGNC:APP), p(HGNC:APP)) View Subject | View Object

The E1 domain is reported to function as the major interaction interface for dimerization of cellular APP/APLPs (Soba et al. 2005) PubMed:22122372

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MeSH
Neurons

complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APP), p(HGNC:APP)) View Subject | View Object

Furthermore, the E1 and E2 regions of APP were found to interact with themselves, in parallel or anti-parallel, forming homo- (with APP) or hetero-dimers (with APLPs) (Wang and Ha 2004; Soba et al. 2005; Dahms et al. 2010) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

Out-Edges 1

complex(p(HGNC:APP), p(HGNC:APP)) hasComponent p(HGNC:APP) View Subject | View Object

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.