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bp(GO:"GO:0043491")

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Entity

Name
GO:0043491
Namespace
go
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/go.belns

Appears in Networks 1

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

In-Edges 5

act(p(HGNC:NGFR)) increases bp(GO:"GO:0043491") View Subject | View Object

Recent evidence supports the notion that p75NTR has an intrinsic signaling capacity including: • Sphingolipid metabolism [98–100] • Activation of the JNK pathway [52,54,56,101–103] • Activation of the NF-kappaB pathway [104–109] • Activation of the Akt pathway [110] • Activation of the MAPK pathway [97,111] PubMed:18986241

Appears in Networks:
Annotations
MeSH
Cognitive Dysfunction

p(FPLX:RAS) association bp(GO:"GO:0043491") View Subject | View Object

A second downstream pathway is the PI3K/Akt pathway that regulates neurotrophin-mediated survival responses in PC12 cells [90,91]. Regulation of this pathway involves upstream elements including Ras/Gab1/IRS1 [92,93]. PubMed:18986241

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12
MeSH
Cognitive Dysfunction

p(HGNC:GAB1) association bp(GO:"GO:0043491") View Subject | View Object

A second downstream pathway is the PI3K/Akt pathway that regulates neurotrophin-mediated survival responses in PC12 cells [90,91]. Regulation of this pathway involves upstream elements including Ras/Gab1/IRS1 [92,93]. PubMed:18986241

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12
MeSH
Cognitive Dysfunction

p(HGNC:IRS1) association bp(GO:"GO:0043491") View Subject | View Object

A second downstream pathway is the PI3K/Akt pathway that regulates neurotrophin-mediated survival responses in PC12 cells [90,91]. Regulation of this pathway involves upstream elements including Ras/Gab1/IRS1 [92,93]. PubMed:18986241

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12
MeSH
Cognitive Dysfunction

p(HGNC:NTRK1, pmod(Ph)) increases bp(GO:"GO:0043491") View Subject | View Object

Gambogic amide binds selectively to TrkA (but not TrkB or TrkC), phosphorylates TrkA tyrosine residues, and activates the Akt and MAPK TrkA-mediated NGF signaling pathways. Gambogic amide has been demonstrated to ameliorate excitotoxic damage and promote neurite outgrowth in PC12 cells [116], making this a potential lead compound for chemical modification and clinical trial assessment. PubMed:18986241

Appears in Networks:
Annotations
MeSH
Cognitive Dysfunction

Out-Edges 4

bp(GO:"GO:0043491") regulates bp(MESH:D002470) View Subject | View Object

A second downstream pathway is the PI3K/Akt pathway that regulates neurotrophin-mediated survival responses in PC12 cells [90,91]. Regulation of this pathway involves upstream elements including Ras/Gab1/IRS1 [92,93]. PubMed:18986241

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12
MeSH
Cognitive Dysfunction

bp(GO:"GO:0043491") association p(FPLX:RAS) View Subject | View Object

A second downstream pathway is the PI3K/Akt pathway that regulates neurotrophin-mediated survival responses in PC12 cells [90,91]. Regulation of this pathway involves upstream elements including Ras/Gab1/IRS1 [92,93]. PubMed:18986241

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12
MeSH
Cognitive Dysfunction

bp(GO:"GO:0043491") association p(HGNC:IRS1) View Subject | View Object

A second downstream pathway is the PI3K/Akt pathway that regulates neurotrophin-mediated survival responses in PC12 cells [90,91]. Regulation of this pathway involves upstream elements including Ras/Gab1/IRS1 [92,93]. PubMed:18986241

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12
MeSH
Cognitive Dysfunction

bp(GO:"GO:0043491") association p(HGNC:GAB1) View Subject | View Object

A second downstream pathway is the PI3K/Akt pathway that regulates neurotrophin-mediated survival responses in PC12 cells [90,91]. Regulation of this pathway involves upstream elements including Ras/Gab1/IRS1 [92,93]. PubMed:18986241

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12
MeSH
Cognitive Dysfunction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.