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p(HGNC:SLC7A11)

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Entity

Name
SLC7A11
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation v1.0.0

In-Edges 2

a(CHEBI:cocaine) decreases act(p(HGNC:SLC7A11)) View Subject | View Object

This antiporter was recently found to be decreased by repeated cocaine exposure, and restoration of the activity prevented cocaine-primed drug seeking behavior in rats (Baker et al., 2003). PubMed:22020111

Appears in Networks:

a(PUBCHEM:135316034) increases p(HGNC:SLC7A11) View Subject | View Object

SLC7A11, induced 76-fold, encodes a cystine/glutamate antiporter responsible for maintaining extracellular glutamate in the brain, and for importing cystine necessary for glutathione synthesis (Albrecht et al., 2010). PubMed:22020111

Appears in Networks:

Out-Edges 2

p(HGNC:SLC7A11) regulates bp(GO:"glutamate homeostasis") View Subject | View Object

SLC7A11, induced 76-fold, encodes a cystine/glutamate antiporter responsible for maintaining extracellular glutamate in the brain, and for importing cystine necessary for glutathione synthesis (Albrecht et al., 2010). PubMed:22020111

Appears in Networks:
Annotations
MeSH
Brain

p(HGNC:SLC7A11) increases tloc(a(CHEBI:cystine), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) View Subject | View Object

SLC7A11, induced 76-fold, encodes a cystine/glutamate antiporter responsible for maintaining extracellular glutamate in the brain, and for importing cystine necessary for glutathione synthesis (Albrecht et al., 2010). PubMed:22020111

Appears in Networks:
Annotations
MeSH
Brain

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.