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p(HBP:"6D tau")

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Entity

Name
6D tau
Namespace
HBP
Namespace Version
None
Pattern
.*

Appears in Networks 1

Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. v1.0.0

In-Edges 1

p(HBP:"6D tau", frag("2_18")) association act(p(HBP:"6D tau")) View Subject | View Object

As observed with 􏰁2–18 tau aggregates (LaPointe et al., 2009), monomeric 􏰁2–18 6D tau showed no effect on FAT (Fig. 4 A, D), demonstrating that PAD is necessary for 6D tau- mediated inhibition of anterograde FAT. PubMed:21734277

Appears in Networks:

Out-Edges 7

p(HBP:"6D tau") hasVariant p(HBP:"6D tau", frag("2_18")) View Subject | View Object

Appears in Networks:

act(p(HBP:"6D tau")) association p(HBP:"6D tau", frag("2_18")) View Subject | View Object

As observed with 􏰁2–18 tau aggregates (LaPointe et al., 2009), monomeric 􏰁2–18 6D tau showed no effect on FAT (Fig. 4 A, D), demonstrating that PAD is necessary for 6D tau- mediated inhibition of anterograde FAT. PubMed:21734277

Appears in Networks:

p(HBP:"6D tau") decreases bp(GO:"anterograde axonal protein transport") View Subject | View Object

perfusion of full-length WT tau monomers (2 􏰊M) (Fig. 1 A) had no effect on FAT in squid axoplasm (Fig. 2 A), while 6D and 6P tau monomers (2 􏰊M) significantly inhibited anterograde FAT when compared with WT tau monomer (Fig. 2 B, C) or buf- fer controls (data not shown). PubMed:21734277

Appears in Networks:

p(HBP:"6D tau") decreases bp(GO:"anterograde axonal protein transport") View Subject | View Object

Together, these data demonstrate that, as posited for aggregated tau (LaPointe et al., 2009), short N-terminal isoforms of tau inhibit anterograde FAT by a mech- anism involving activation of PP1 and GSK3 that is independent of microtubule binding. PubMed:21734277

Appears in Networks:

p(HBP:"6D tau") causesNoChange bp(GO:"retrograde axonal protein transport") View Subject | View Object

Neither 6D nor 6P tau (Fig. 2D) had an effect on retrograde FAT PubMed:21734277

Appears in Networks:

p(HBP:"6D tau") increases act(p(MESH:"Protein Phosphatase 1")) View Subject | View Object

Together, these data demonstrate that, as posited for aggregated tau (LaPointe et al., 2009), short N-terminal isoforms of tau inhibit anterograde FAT by a mech- anism involving activation of PP1 and GSK3 that is independent of microtubule binding. PubMed:21734277

Appears in Networks:

p(HBP:"6D tau") increases act(p(MESH:"Glycogen Synthase Kinase 3")) View Subject | View Object

Together, these data demonstrate that, as posited for aggregated tau (LaPointe et al., 2009), short N-terminal isoforms of tau inhibit anterograde FAT by a mech- anism involving activation of PP1 and GSK3 that is independent of microtubule binding. PubMed:21734277

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.