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Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:23:08.425076
Authors
Lingling Xu
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
21
Number Edges
42
Number Components
1
Network Density
0.1
Average Degree
2.0
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. v1.0.0 33%
Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease v1.0.0 33%
Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0 29%
Alzheimer’s disease and the autophagic-lysosomal system v1.0.0 29%
Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0 25%
Tau in physiology and pathology v1.0.0 24%
Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies v1.0.0 19%
Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β. v1.0.0 19%
Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies v1.0.0 19%
Tau oligomers and tau toxicity in neurodegenerative disease v1.0.0 19%

Sample Edges

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

a(HBP:"I-2") increases act(p(HBP:"6D tau", frag("2_18"))) View Subject | View Object

Again, coperfusion of the PAD peptide with either I-2 (50 nM) (Fig. 5A) or ING-135 (100 nM) (Fig. 5B) anterograde FAT inhibition. PubMed:21734277

a(HBP:"ING-135") increases act(p(HBP:"6D tau", frag("2_18"))) View Subject | View Object

Again, coperfusion of the PAD peptide with either I-2 (50 nM) (Fig. 5A) or ING-135 (100 nM) (Fig. 5B) anterograde FAT inhibition. PubMed:21734277

bp(GO:"anterograde axonal protein transport") association p(HBP:"6D tau", frag("2_18")) View Subject | View Object

As observed with 􏰁2–18 tau aggregates (LaPointe et al., 2009), monomeric 􏰁2–18 6D tau showed no effect on FAT (Fig. 4 A, D), demonstrating that PAD is necessary for 6D tau- mediated inhibition of anterograde FAT. PubMed:21734277

complex(p(HBP:"6D tau", frag("2_18")), p(HBP:PAD)) hasComponent p(HBP:"6D tau", frag("2_18")) View Subject | View Object

Sample Nodes

path(MESH:"Alzheimer Disease")

In-Edges: 536 | Out-Edges: 704 | Classes: 5 | Explore Neighborhood | Download JSON

p(HGNC:MAPT)

In-Edges: 477 | Out-Edges: 480 | Classes: 11 | Children: 27 | Explore Neighborhood | Download JSON

p(HGNC:MAPT, pmod(Ph))

In-Edges: 201 | Out-Edges: 71 | Classes: 1 | Children: 4 | Explore Neighborhood | Download JSON

bp(GO:"anterograde axonal protein transport")

In-Edges: 26 | Out-Edges: 2 | Explore Neighborhood | Download JSON

bp(GO:"axonal transport")

In-Edges: 24 | Out-Edges: 8 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.