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m(MIRBASE:"hsa-mir-125b-2")

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Entity

Name
hsa-mir-125b-2
Namespace
mirbase
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/mirbase-names.belns

Appears in Networks 1

Upstream regulators and downstream effectors of NF-κBinAlzheimer's disease v1.0.0

In-Edges 1

p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-125b-2") View Subject | View Object

Inducible miRNAs and lncRNA perform critical regulatory roles in CNS development, several brain-enriched miRNAs are consistently up- regulated by NF-κB, including miRNA-125b [66], miRNA-146a [67] and miRNA-155 [68]. PubMed:27288790

Appears in Networks:

Out-Edges 2

m(MIRBASE:"hsa-mir-125b-2") decreases p(HGNC:ALOX15) View Subject | View Object

Pathogenic effects appear to be mediated via specific interaction of miRNA-125b with the 3′-UTR region of mRNA of 15-lipoxygenase (15-LOX) and the vitamin D3 receptor (VDR; VD3R), the downregula- tion of 15-LOX and VDR may therefore be explained by the actions of a single inducible, pro-inflammatory miRNA-125b in hippocampal CA1 of AD brain [71]. PubMed:27288790

Appears in Networks:
Annotations
MeSH
CA1 Region, Hippocampal
MeSH
Alzheimer Disease

m(MIRBASE:"hsa-mir-125b-2") decreases p(HGNC:VDR) View Subject | View Object

Pathogenic effects appear to be mediated via specific interaction of miRNA-125b with the 3′-UTR region of mRNA of 15-lipoxygenase (15-LOX) and the vitamin D3 receptor (VDR; VD3R), the downregula- tion of 15-LOX and VDR may therefore be explained by the actions of a single inducible, pro-inflammatory miRNA-125b in hippocampal CA1 of AD brain [71]. PubMed:27288790

Appears in Networks:
Annotations
MeSH
CA1 Region, Hippocampal
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.