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p(HGNC:MAPT, pmod(Ph, Tyr, 394))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 4

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies v1.0.0

Tau Biochemistry v1.2.5

Tau Biochemistry Section of NESTOR

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Tau in physiology and pathology v1.0.0

In-Edges 7

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 394)) View Subject | View Object

The phosphorylation of tau at Tyr394 and Tyr18 is present in PHFs in the brains of individuals with AD. PubMed:26631930

Appears in Networks:

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(Ph, Tyr, 394)) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 394)) View Subject | View Object

3. Putative phosphorylation sites on tau protein and epitopes specific for major tau antibodies. Red color denotes amino acids phosphorylation in AD brain. PubMed:26751493

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:ABL1) increases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) View Subject | View Object

Tyrosine kinases target Y18 [fyn, (79)] and Y394 [abl, (31)]. PubMed:17493042

Appears in Networks:
Annotations
Uberon
brain

a(HBP:"paired helical filaments") association p(HGNC:MAPT, pmod(Ph, Tyr, 394)) View Subject | View Object

The phosphorylation of tau at Tyr394 and Tyr18 is present in PHFs in the brains of individuals with AD. PubMed:26631930

Appears in Networks:

p(HGNC:ABL1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) View Subject | View Object

In addition, tau can be phosphorylated by tyrosine kinases such as the SRC family members LCK, SYK and FYN at Tyr18, and the ABL family members ARG and ABL1 at Tyr394 (REF. 45). PubMed:26631930

Appears in Networks:

p(HGNC:ABL2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) View Subject | View Object

In addition, tau can be phosphorylated by tyrosine kinases such as the SRC family members LCK, SYK and FYN at Tyr18, and the ABL family members ARG and ABL1 at Tyr394 (REF. 45). PubMed:26631930

Appears in Networks:

Out-Edges 3

p(HGNC:MAPT, pmod(Ph, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

The phosphorylation of tau at Tyr394 and Tyr18 is present in PHFs in the brains of individuals with AD. PubMed:26631930

Appears in Networks:

p(HGNC:MAPT, pmod(Ph, Tyr, 394)) association a(HBP:"paired helical filaments") View Subject | View Object

The phosphorylation of tau at Tyr394 and Tyr18 is present in PHFs in the brains of individuals with AD. PubMed:26631930

Appears in Networks:

p(HGNC:MAPT, pmod(Ph, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

3. Putative phosphorylation sites on tau protein and epitopes specific for major tau antibodies. Red color denotes amino acids phosphorylation in AD brain. PubMed:26751493

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.