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In-Edges 9

a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:AK1) View Subject | View Object

Therefore, we examined whether oligomeric forms of Ab42 could regulate AK1 expression in neuronal cells. PubMed:22419736

a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1) View Subject | View Object

From western blot analysis, we found that AK1 expression increased 􏰍2-fold in the cortical neurons after exposure to Ab42 PubMed:22419736

a(CHEBI:"amyloid-beta polypeptide 42") association act(p(HGNC:AK1)) View Subject | View Object

As shown in Figure 5A and B, treatment of control cells with Ab42 reduced the levels of AMPK phosphorylation at Thr172 and the inhibitory phosphorylation of GSK3b at Ser9. On the contrary, these alterations triggered by Ab42 were not observed in SH-SY5Y/AK1 knockdown cells, showing no changes in the levels of the phosphorylated AMPK and GSK3b. These results suggest that AK1 plays a crucial role in the regulation of AMPK and GSK3b in the neuronal cells exposed to Ab42. PubMed:22419736

bp(GO:"response to oxidative stress") increases p(HGNC:AK1) View Subject | View Object

AK1 expression also increased in neuronal cells which were exposed to oxidative stress but not to other toxic insults, such as proteostasis stressors PubMed:22419736

p(HGNC:APP) positiveCorrelation p(HGNC:AK1) View Subject | View Object

AK1 also increased in the hippocampus of APP-J20, an AD model mouse expressing familial AD-mutant APP (Supple- mentary Material, Fig. S1A and B). PubMed:22419736

p(HGNC:APP, var("c.27269938A>C"), var("c.27269939G>T")) positiveCorrelation p(HGNC:AK1) View Subject | View Object

the AK1 level was higher in the hippocampus of 9-, 12- and 15-month-old Tg2576 mice expressing Swedish mutant of amyloid precursor protein (hAPP) PubMed:22419736

path(MESH:"Alzheimer Disease") increases p(HGNC:AK1) View Subject | View Object

With the immunohisto- chemical analysis, we found that the expression levels of AK1 markedly elevated in the NeuN-positive hippocampal neurons of AD patients PubMed:22419736

Out-Edges 17

p(HGNC:AK1) positiveCorrelation p(HGNC:APP, var("c.27269938A>C"), var("c.27269939G>T")) View Subject | View Object

the AK1 level was higher in the hippocampus of 9-, 12- and 15-month-old Tg2576 mice expressing Swedish mutant of amyloid precursor protein (hAPP) PubMed:22419736

p(HGNC:AK1) positiveCorrelation p(HGNC:APP) View Subject | View Object

AK1 also increased in the hippocampus of APP-J20, an AD model mouse expressing familial AD-mutant APP (Supple- mentary Material, Fig. S1A and B). PubMed:22419736

p(HGNC:AK1) decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) View Subject | View Object

Compared with control neurons, the effects of Ab42 on tau phosphorylation at CP13, PHF-1 and AT180 epitopes were significantly ameliorated in AK1 knockdown cortical neurons PubMed:22419736

act(p(HGNC:AK1)) association a(CHEBI:"amyloid-beta polypeptide 42") View Subject | View Object

As shown in Figure 5A and B, treatment of control cells with Ab42 reduced the levels of AMPK phosphorylation at Thr172 and the inhibitory phosphorylation of GSK3b at Ser9. On the contrary, these alterations triggered by Ab42 were not observed in SH-SY5Y/AK1 knockdown cells, showing no changes in the levels of the phosphorylated AMPK and GSK3b. These results suggest that AK1 plays a crucial role in the regulation of AMPK and GSK3b in the neuronal cells exposed to Ab42. PubMed:22419736

p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 202))) View Subject | View Object

Ectopic expression of AK1 in mouse cortical neurons increased immunoreactivity against phosphorylated tau at Ser396/404 (PHF-1), Ser202 (CP13) and Ser231/Thr235 (AT180) PubMed:22419736

p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 396))) View Subject | View Object

Ectopic expression of AK1 in mouse cortical neurons increased immunoreactivity against phosphorylated tau at Ser396/404 (PHF-1), Ser202 (CP13) and Ser231/Thr235 (AT180) PubMed:22419736

p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 404))) View Subject | View Object

Ectopic expression of AK1 in mouse cortical neurons increased immunoreactivity against phosphorylated tau at Ser396/404 (PHF-1), Ser202 (CP13) and Ser231/Thr235 (AT180) PubMed:22419736

p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 231))) View Subject | View Object

Ectopic expression of AK1 in mouse cortical neurons increased immunoreactivity against phosphorylated tau at Ser396/404 (PHF-1), Ser202 (CP13) and Ser231/Thr235 (AT180) PubMed:22419736

p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 235))) View Subject | View Object

Ectopic expression of AK1 in mouse cortical neurons increased immunoreactivity against phosphorylated tau at Ser396/404 (PHF-1), Ser202 (CP13) and Ser231/Thr235 (AT180) PubMed:22419736

p(HGNC:AK1) increases p(HBP:"Tau aggregates") View Subject | View Object

The data suggest that the increased expres- sion of AK1 can enhance tau aggregation as well as tau phos- phorylation. PubMed:22419736

p(HGNC:AK1) increases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

The data suggest that the increased expres- sion of AK1 can enhance tau aggregation as well as tau phos- phorylation. PubMed:22419736

p(HGNC:AK1) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) View Subject | View Object

In addition, we found that transient expression of AK1 (but not AK1 R132A mutant) markedly reduced the inhibitory phosphorylation of GSK3b at Ser9 (Fig. 4D and Supplemen- tary Material, S6A), indicating that AK1 may regulate GSK3b activity. PubMed:22419736

p(HGNC:AK1) regulates p(ECCODE:"2.7.11.31") View Subject | View Object

As shown in Figure 5A and B, treatment of control cells with Ab42 reduced the levels of AMPK phosphorylation at Thr172 and the inhibitory phosphorylation of GSK3b at Ser9. On the contrary, these alterations triggered by Ab42 were not observed in SH-SY5Y/AK1 knockdown cells, showing no changes in the levels of the phosphorylated AMPK and GSK3b. These results suggest that AK1 plays a crucial role in the regulation of AMPK and GSK3b in the neuronal cells exposed to Ab42. PubMed:22419736

p(HGNC:AK1) regulates p(HGNC:GSK3B) View Subject | View Object

As shown in Figure 5A and B, treatment of control cells with Ab42 reduced the levels of AMPK phosphorylation at Thr172 and the inhibitory phosphorylation of GSK3b at Ser9. On the contrary, these alterations triggered by Ab42 were not observed in SH-SY5Y/AK1 knockdown cells, showing no changes in the levels of the phosphorylated AMPK and GSK3b. These results suggest that AK1 plays a crucial role in the regulation of AMPK and GSK3b in the neuronal cells exposed to Ab42. PubMed:22419736

p(HGNC:AK1) increases path(MESH:"Retinal Degeneration") View Subject | View Object

Co-expression of an AK1 transgene with tau in flies (gl-tau2.1/UAS-AK1) markedly enhanced tau-induced retinal degeneration,indicating that AK1 enhances tau toxicity in the fly retina. PubMed:22419736

p(HGNC:AK1) increases path(MESH:"Retinal Degeneration") View Subject | View Object

These results indicate that AK1 exacerbates rough eye phenotype and tau hyperpho- sphorylation in a tauopathy model organism and that there is a close correlation between the exacerbated rough eye pheno- type and tau phosphorylation. PubMed:22419736

p(HGNC:AK1) increases act(p(HGNC:MAPT)) View Subject | View Object

Co-expression of an AK1 transgene with tau in flies (gl-tau2.1/UAS-AK1) markedly enhanced tau-induced retinal degeneration,indicating that AK1 enhances tau toxicity in the fly retina. PubMed:22419736

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.