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complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat"))

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Components

Appears in Networks 1

Assembly and structure of protein phosphatase 2A v1.0.0

In-Edges 3

p(HGNC:PPP2CA) increases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) View Subject | View Object

Structures of the PP2A core enzyme reveal that the catalytic subunit recognizes one end of the scaffold subunit through interactions with the conserved ridge of HEAT repeats 11–15 PubMed:19277525

Appears in Networks:

p(INTERPRO:"HEAT repeat", var("p.Arg418Trp")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) View Subject | View Object

The important interactions mediated by Arg418 and Val533 (corresponding to Val545 in the β isoform) provide a plausible explanation to the biochemical finding that these mutations crippled binding to the catalytic subunit PubMed:19277525

Appears in Networks:

p(INTERPRO:"HEAT repeat", var("p.Val545Ala")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) View Subject | View Object

The important interactions mediated by Arg418 and Val533 (corresponding to Val545 in the β isoform) provide a plausible explanation to the biochemical finding that these mutations crippled binding to the catalytic subunit PubMed:19277525

Appears in Networks:

Out-Edges 2

complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) hasComponent p(HGNC:PPP2CA) View Subject | View Object

Appears in Networks:

complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) hasComponent p(INTERPRO:"HEAT repeat") View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.