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  3. p(INTERPRO:"HEAT repeat", var("p.Arg418Trp")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat"))

p(INTERPRO:"HEAT repeat", var("p.Arg418Trp")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat"))

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Assembly and structure of protein phosphatase 2A v1.0.0

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PubMed:19277525

The important interactions mediated by Arg418 and Val533 (corresponding to Val545 in the β isoform) provide a plausible explanation to the biochemical finding that these mutations crippled binding to the catalytic subunit

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.