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p(HGNC:PRNP)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
PRNP
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 3

Amyloid β oligomers (AβOs) in Alzheimer’s disease v1.0.0

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage from Shafiei et al., 2017

In-Edges 8

complex(a(HBP:HBP00074), p(HGNC:PRNP)) hasComponent p(HGNC:PRNP) View Subject | View Object

Appears in Networks:

complex(p(HGNC:GRIK1), p(HGNC:PRNP)) hasComponent p(HGNC:PRNP) View Subject | View Object

Appears in Networks:

complex(p(HGNC:HSPA5), p(HGNC:PRNP)) hasComponent p(HGNC:PRNP) View Subject | View Object

Appears in Networks:

bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PRNP)) View Subject | View Object

Once in the cytoplasm, the PrPc would be efficiently degraded by the UPS via the ERAD pathway, but this does not occur in the presence of the proteasome inhibitors PubMed:14556719

Appears in Networks:

bp(GO:aging) increases p(HGNC:PRNP) View Subject | View Object

Lindquist and colleagues proposed that inhibition of UPS, which can be caused by ageing or following a pharmacological treatment, can lead to accumulation of PrPc in the cytoplasm where it is spontaneously converted into a PrPsc-like species because it is not rapidly degraded by the UPS (Hooper, 2003; Ma and Lindquist,2002;Ma et al., 2002). PubMed:14556719

Appears in Networks:

complex(a(CHEBI:"copper(2+)"), p(HGNC:PRNP)) hasComponent p(HGNC:PRNP) View Subject | View Object

Appears in Networks:

tloc(p(HGNC:PRNP), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(GO:cytosol)) increases deg(p(HGNC:PRNP)) View Subject | View Object

Once in the cytoplasm, the PrPc would be efficiently degraded by the UPS via the ERAD pathway, but this does not occur in the presence of the proteasome inhibitors PubMed:14556719

Appears in Networks:

a(HBP:"Tau oligomers") association p(HGNC:PRNP) View Subject | View Object

Recently, data has shown that injected tau oligomers colocalize with the mitochondrial marker porin, suggesting a pathological relationship PubMed:28420982

Appears in Networks:
Annotations
MeSH
Extracellular Space
Confidence
High
MeSH
Neurons
MeSH
Alzheimer Disease

Out-Edges 5

p(HGNC:PRNP) decreases a(CHEBI:"amyloid fibril") View Subject | View Object

Moreover, PrPC inhibits formation fibrillary form of Aβ, trapping Aβ in an oligomeric state (Younan et al. 2013). PubMed:29196815

Appears in Networks:
Annotations
MeSH
Extracellular Space
Cell Ontology (CL)
neuron
Confidence
High
MeSH
Hippocampus

p(HGNC:PRNP) hasVariant p(HGNC:PRNP, pmod(HBP:misfolding)) View Subject | View Object

Appears in Networks:

p(HGNC:PRNP) increases complex(a(CHEBI:"copper(2+)"), p(HGNC:PRNP)) View Subject | View Object

PrPc is abundant in many cells throughout the body, particularly in the immune and nervous systems, and is typically anchored to the outer cell membrane, where it may act as a copper binding protein with antioxidant properties (Brown,2002). PubMed:14556719

Appears in Networks:

tloc(p(HGNC:PRNP), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(GO:cytosol)) increases deg(p(HGNC:PRNP)) View Subject | View Object

Once in the cytoplasm, the PrPc would be efficiently degraded by the UPS via the ERAD pathway, but this does not occur in the presence of the proteasome inhibitors PubMed:14556719

Appears in Networks:

p(HGNC:PRNP) association a(HBP:"Tau oligomers") View Subject | View Object

Recently, data has shown that injected tau oligomers colocalize with the mitochondrial marker porin, suggesting a pathological relationship PubMed:28420982

Appears in Networks:
Annotations
MeSH
Extracellular Space
Confidence
High
MeSH
Neurons
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.