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p(HGNC:PPP2R5E)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
PPP2R5E
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer v1.0.0

In-Edges 3

p(FPLX:"PPP2R_B") hasComponent p(HGNC:PPP2R5E) View Subject | View Object

Appears in Networks:

p(HBP:"APOE e4") directlyDecreases p(HGNC:PPP2R5E) View Subject | View Object

Our results indicated a significant down-regulation of PPP2R5E gene expression and reduction in PP2A activity by ApoE4 compared with ApoE3. This may also explain an elevated Tau phosphorylation in AD human brains that featured at least one ApoE4 allele. PubMed:28720530

Appears in Networks:

a(MESH:Cytosol) association p(HGNC:PPP2R5E) View Subject | View Object

Intracellular localization of B56 isoforms vary, as B56 γ is expressed in the nucleus while B56 α , B56 β , and B56 ε are expressed in the cytoplasm, and PR61 δ appears to be expressed in both the nucleus and cytoplasm [20]. PubMed:23454242

Appears in Networks:

Out-Edges 2

p(HGNC:PPP2R5E) partOf complex(GO:"protein phosphatase type 2A complex") View Subject | View Object

Appears in Networks:

p(HGNC:PPP2R5E) association a(MESH:Cytosol) View Subject | View Object

Intracellular localization of B56 isoforms vary, as B56 γ is expressed in the nucleus while B56 α , B56 β , and B56 ε are expressed in the cytoplasm, and PR61 δ appears to be expressed in both the nucleus and cytoplasm [20]. PubMed:23454242

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.