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r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")

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Entity

Name
Cholinergic receptors nicotinic subunits
Namespace
hgnc.genefamily
Namespace Version
20181015
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/3074b85b858455d8eeb76cfcdef685ced19bbe11/external/hgnc.genefamily-names.belns

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albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0

In-Edges 7

a(CHEBI:"amyloid-beta polypeptide 42") decreases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") View Subject | View Object

It is noteworthy that the alpha7 nAChR activity increases intracellular accumulation of Abeta in neurons (336), and Abeta peptides, in addition to modulating nAChR activity, downregulate the expression of nAChRs (197). PubMed:19126755

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Neurons
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a(MESH:"Cell Line") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") View Subject | View Object

For example, Loring and colleagues (458) compared the relative expression of alpah4beta2 versus alpha7 nAChRs transfected into five different cell lines (GH4C1, SH-EP1, CV1, SN-56, and CHOCAR). Each cell line expressed appropriate mRNAs (indicating successful transfection); however, the relative levels of expression of each receptor subtype varied significantly among the various cell lines. PubMed:19126755

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bp(GO:"MAPK cascade") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") View Subject | View Object

In cell lines, this interaction of trans-activating components is also under the regulation of the Ras-dependent MAPK and pathways related to phosphoinositide-3-kinase (PI3K) and MEK activation whose response to trophic factors such as nerve growth factor (NGF) contributes to regulating transcript initiation. PubMed:19126755

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bp(GO:"phosphatidylinositol 3-kinase signaling") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") View Subject | View Object

In cell lines, this interaction of trans-activating components is also under the regulation of the Ras-dependent MAPK and pathways related to phosphoinositide-3-kinase (PI3K) and MEK activation whose response to trophic factors such as nerve growth factor (NGF) contributes to regulating transcript initiation. PubMed:19126755

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p(HGNC:NGF) regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") View Subject | View Object

As was noted above, in different laboratories, these cells were reported to regulate nAChR mRNA expression differently in response to nerve growth factor, and to exhibit dramatically different expression of alpha7 nAChRs. PubMed:19126755

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act(p(HGNC:SOX10)) increases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") View Subject | View Object

Also central to restricting (or at least limiting) the expression of these transcripts to predominantly neuronal-like cell lines (Neuro2A and NGF-treated PC12) are interactions among other factors including SCIP/Tst- 1/Oct-6 and transactivation by Sox10 (66, 268, 317, 513). PubMed:19126755

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path(MESH:"Alzheimer Disease") causesNoChange r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") View Subject | View Object

More recent approaches have confirmed this: RNA profiling of isolated neurons from control brains or brains from patients with AD show no evidence for changes in nAChR RNA (Chow et al., 1998; Ginsberg et al., 2000). PubMed:19293145

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Out-Edges 1

r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(HBP:"nAChR assembly") View Subject | View Object

When cRNAs encoding specific nAChR subunits are introduced into Xenopus oocytes, simple (alpha3beta4) as well as more complex (muscle alpha1beta1deltagamma) heteromeric receptors are assembled and expressed on the cell surface (341). In Xenopus oocytes, these heteromeric nAChRs are assembled and expressed with almost equivalent efficiencies as the homomeric 5HT3A receptor (341). PubMed:19126755

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.