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a(CHEBI:"Hsp90 inhibitor")

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Entity

Name
Hsp90 inhibitor
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 2

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies v1.0.0

In-Edges 1

a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") decreases act(a(CHEBI:"Hsp90 inhibitor")) View Subject | View Object

For example, treatment of primary neurons with an Hsp90 inhibitor to interrupt the proper chaperoning of tau leads to decreased levels of tau. Adding MG-132 to block the proteasome prevented the Hsp90 inhibitor-induced reduction in total tau. MG-132 alone had no effect on tau levels (67). PubMed:24027553

Appears in Networks:
Annotations
Text Location
Review

Out-Edges 3

act(a(CHEBI:"Hsp90 inhibitor")) decreases p(HGNC:MAPT) View Subject | View Object

For example, treatment of primary neurons with an Hsp90 inhibitor to interrupt the proper chaperoning of tau leads to decreased levels of tau. Adding MG-132 to block the proteasome prevented the Hsp90 inhibitor-induced reduction in total tau. MG-132 alone had no effect on tau levels (67). PubMed:24027553

Appears in Networks:
Annotations
Text Location
Review

a(CHEBI:"Hsp90 inhibitor") increases deg(p(HGNC:MAPT)) View Subject | View Object

For example, Hsp90 inhibitors cause degradation of tau and many cancer-related substrates [85]. PubMed:21882945

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a(CHEBI:"Hsp90 inhibitor") increases complex(a(MESH:Proteins), p(FPLX:HSP90)) View Subject | View Object

Moreover, these compounds were found to prolong binding of Hsp90 to a model substrate, which was sufficient to promote its degradation [142] PubMed:21882945

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.