1. Catalog
  2. Nodes
  3. a(CHEBI:bilirubin)

a(CHEBI:bilirubin)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
bilirubin
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 4

a(CHEBI:"lead nitrate") increases a(CHEBI:bilirubin) View Subject | View Object

The serum levels of direct bilirubin (DBil) and total bilirubin (TBil) were significantly increased in Ko + Pb mice, compared to those in Ko − Pb mice and Wt + Pb mice (Figure 2C and D; P < 0.05). PubMed:25411909

Appears in Networks:
Annotations
MeSH
Serum
Text Location
Results

act(a(CHEBI:antioxidant)) positiveCorrelation a(CHEBI:bilirubin) View Subject | View Object

Carbon monoxide has vasodilatory, anti-proliferative, anti-inflammatory and antioxidant properties, whereas bilirubin, the product of biliverdin reductase, is an antioxidant (Baranano et al, 2002). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

a(HM:"Blood Transfusion, Acute") increases a(CHEBI:bilirubin) View Subject | View Object

Acute large volume blood transfusion or administration of blood units at later stages of storage causes elevation of bilirubin, Tf saturation and LPI in animals [18&&] and humans [19&&]. PubMed:30281034

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

path(MESH:"Porphyria, Erythropoietic") positiveCorrelation a(CHEBI:bilirubin) View Subject | View Object

Congenital erythropoietic porphyria mice showed increased serum bilirubin and LDH levels (Table 1), with almost undetectable levels of Hp and Hpx (Figure 1A and B, respectively), which was strongly indicative of hemolytic anemia. PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Serum
Text Location
Results

Out-Edges 2

a(CHEBI:bilirubin) positiveCorrelation act(a(CHEBI:antioxidant)) View Subject | View Object

Carbon monoxide has vasodilatory, anti-proliferative, anti-inflammatory and antioxidant properties, whereas bilirubin, the product of biliverdin reductase, is an antioxidant (Baranano et al, 2002). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Review

a(CHEBI:bilirubin) positiveCorrelation path(MESH:"Porphyria, Erythropoietic") View Subject | View Object

Congenital erythropoietic porphyria mice showed increased serum bilirubin and LDH levels (Table 1), with almost undetectable levels of Hp and Hpx (Figure 1A and B, respectively), which was strongly indicative of hemolytic anemia. PubMed:28143953

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Serum
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.