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bp(GO:"generation of neurons")

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Entity

Name
generation of neurons
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 3

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage from Shafiei et al., 2017

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0

In-Edges 4

act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"generation of neurons") View Subject | View Object

The neurodevelopmental program depends in part on alpha7 signaling (Liu et al.,2006) PubMed:21482353

Appears in Networks:

p(HGNC:LYNX1) regulates bp(GO:"generation of neurons") View Subject | View Object

Lynx1 upregulation during a critical neurodevelopmental period, the switch in the sign of GABAergic signaling, and coexpression of lynx with GABAergic subsets all indicate a possible role of lynx mediating the timing of such developmental transitions PubMed:21482353

Appears in Networks:

p(HGNC:MAPT) regulates bp(GO:"generation of neurons") View Subject | View Object

While functional tau is an unfolded monomeric protein that stabilizes microtubules, regulates neurite growth, and monitors axonal transport of organelles (Medina and Avila, 2014), dysfunctional tau acquires a new toxic function PubMed:28420982

Appears in Networks:
Annotations
Confidence
High

complex(p(HGNC:ERBB4), p(HGNC:NRG1)) regulates bp(GO:"generation of neurons") View Subject | View Object

In particular, NRG1, which is mostly involved in regulating neurodevelopment and neurotransmission, acts by binding ErbB4, a type I transmembrane receptor tyrosine kinase belonging to the family of ErbB proteins, which contain a binding site for PI3K kinase, an AKT upstream effector, in the C-terminal cytoplasmic tail (CYT) PubMed:30061532

Appears in Networks:

Out-Edges 1

bp(GO:"generation of neurons") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) View Subject | View Object

The neurodevelopmental program depends in part on alpha7 signaling (Liu et al.,2006) PubMed:21482353

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.