1. Catalog
  2. Nodes
  3. path(MESH:"Neuroaxonal Dystrophies")

path(MESH:"Neuroaxonal Dystrophies")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Neuroaxonal Dystrophies
Namespace
mesh
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mesh-names.belns

Appears in Networks 1

Amyloid β oligomers (AβOs) in Alzheimer’s disease v1.0.0

In-Edges 2

a(CHEBI:"amyloid-beta") increases path(MESH:"Neuroaxonal Dystrophies") View Subject | View Object

These Aβ deposits lead to subsequent molecular and cellular alterations, such as NTFs, neuronal dystrophy, or microgliosis, i.e., pathological events that are closer to dementia and more relevant to neuronal dysfunction. PubMed:29196815

Appears in Networks:
Annotations
Confidence
Medium

a(HBP:HBP00074) increases path(MESH:"Neuroaxonal Dystrophies") View Subject | View Object

AβOs can trigger changes in Tau protein characteristic for AD (Shankar et al. 2008). They induce hyperphosphorylation of Tau at AD-specific epitopes and cause neuritic dystrophy in cultured neurons. PubMed:29196815

Appears in Networks:
Annotations
MeSH
Extracellular Space
Cell Ontology (CL)
neuron
Confidence
Medium

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.