bp(MESH:"Endoplasmic Reticulum Stress")

Entity

Name

Endoplasmic Reticulum Stress

Namespace

MeSH

Namespace Version

20181007

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

furthermore, treatment with salubrinal, which alleviates ER stress, reduced oligomeric accumulation in the ER. PubMed:28803412

Accumulation of oligomers has been demonstrated in a transgenic mouse overexpressing A53T a-syn and in Parkinson’s disease brain tissue, resulting in chronic ER stress and impaired ER protein quality control [25]. PubMed:28803412

In parallel, ER stress promotes the relocation of ATF6 from the ER membrane to the Golgi apparatus, where it is cleaved by SP1 and SP2 proteases. PubMed:25784053

Finally, a third ER transmembrane protein, PERK, promotes translation of the TF ATF4 by phosphorylating the translation initiation factor eIF2α in response to ER stress. PubMed:25784053