Tau isoform F (441 aa)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name: Tau isoform F (441 aa)
Namespace: HBP
Namespace Version: 20181119
Namespace URL: https://raw.githubusercontent.com/pharmacome/terminology/90e1cb9e5e882703380c9db8d4915ac6f3cba137/export/hbp-names.belns

Appears in Networks 1

TAU and Interaction Partners v1.2.5

TAU Interactions Section of NESTOR

In-Edges 1

p(HBP:"Tau isoform F (441 aa)") hasVariant p(HBP:"Tau isoform F (441 aa)", var("p.Val337Met")) View Subject | View Object

Appears in Networks:

TAU and Interaction Partners v1.2.5

Out-Edges 1

p(HBP:"Tau isoform F (441 aa)", var("p.Val337Met")) increases a(HBP:Neurodegeneration) View Subject | View Object

These results are consistent with previous in vitro studies and indicate that tau induces actin-filament bundling in vitro and F-actin accumulation in vivo, most likely through a direct interaction with F-actin.For genetic analysis, we selected a line of tauV337M-expressing flies that has a moderate rough eye and is a good substrate for genetic modification. Coexpressing an actin transgene (UAS–Act5C–EGFP;GMR– GAL4 driver) markedly enhanced tauV337M-induced toxicity. PubMed:17187063

Appears in Networks:

TAU and Interaction Partners v1.2.5

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.