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p(PFAM:GSHPx)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
GSHPx
Namespace
pfam
Namespace Version
20181024
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/8ccfed235e418e4c8aa576f9a5ef0f838e794c7f/external/pfam-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 3

a(CHEBI:"hydrogen peroxide") negativeCorrelation p(PFAM:GSHPx) View Subject | View Object

GPx removes both H2O2 and organic hydroperoxides [8,31] whereas PRDX2 removes H2O2 [2], organic hydroperoxides, lipid hydroperoxides, [32,33] peroxynitrite [34] and protein hydroperoxides [35]. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

a(CHEBI:"hydrogen peroxide") negativeCorrelation p(PFAM:GSHPx) View Subject | View Object

The finding that GPx has a greater role in the inhibition of heme degradation products than catalase [3] is consistent with the primary role of catalase to react with the high concentrations of H2O2 coming from exogenous sources and for GPx to react with the low levels of H2O2 coming from the endogenous autoxidation of Hb [39]. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

a(CHEBI:hydroperoxide) negativeCorrelation p(PFAM:GSHPx) View Subject | View Object

GPx removes both H2O2 and organic hydroperoxides [8,31] whereas PRDX2 removes H2O2 [2], organic hydroperoxides, lipid hydroperoxides, [32,33] peroxynitrite [34] and protein hydroperoxides [35]. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

Out-Edges 3

p(PFAM:GSHPx) negativeCorrelation a(CHEBI:"hydrogen peroxide") View Subject | View Object

GPx removes both H2O2 and organic hydroperoxides [8,31] whereas PRDX2 removes H2O2 [2], organic hydroperoxides, lipid hydroperoxides, [32,33] peroxynitrite [34] and protein hydroperoxides [35]. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

p(PFAM:GSHPx) negativeCorrelation a(CHEBI:"hydrogen peroxide") View Subject | View Object

The finding that GPx has a greater role in the inhibition of heme degradation products than catalase [3] is consistent with the primary role of catalase to react with the high concentrations of H2O2 coming from exogenous sources and for GPx to react with the low levels of H2O2 coming from the endogenous autoxidation of Hb [39]. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

p(PFAM:GSHPx) negativeCorrelation a(CHEBI:hydroperoxide) View Subject | View Object

GPx removes both H2O2 and organic hydroperoxides [8,31] whereas PRDX2 removes H2O2 [2], organic hydroperoxides, lipid hydroperoxides, [32,33] peroxynitrite [34] and protein hydroperoxides [35]. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.