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p(HGNC:MAPT, pmod(UbK63))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo v1.0.0

Tau in physiology and pathology v1.0.0

In-Edges 4

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, pmod(UbK63)) View Subject | View Object

Appears in Networks:

p(HGNC:OTUB1) causesNoChange p(HGNC:MAPT, pmod(UbK63)) View Subject | View Object

Otub1 displayed strong preference for disassembling Lys48-linked polyubiquitin chains, while leaving Lys63-linked polyubiquitin chains unaffected (Fig. 5a). PubMed:28083634

Appears in Networks:

bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT, pmod(UbK63))) View Subject | View Object

Notably, one study demonstrated that tau can also be ubiquitylated through Lys63 linkages by TNF receptor-associated factor 6 (TRAF6) — again, for proteasomal degradation PubMed:26631930

Appears in Networks:

p(HGNC:TRAF6) increases p(HGNC:MAPT, pmod(UbK63)) View Subject | View Object

Notably, one study demonstrated that tau can also be ubiquitylated through Lys63 linkages by TNF receptor-associated factor 6 (TRAF6) — again, for proteasomal degradation PubMed:26631930

Appears in Networks:

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.