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composite(a(CHEBI:choline), p(HGNC:CHRNA7))

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Identification and Characterization of a G Protein-binding Cluster in alpha7 Nicotinic Acetylcholine Receptors v1.0.0

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composite(a(CHEBI:choline), p(HGNC:CHRNA7)) hasComponent a(CHEBI:choline) View Subject | View Object

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composite(a(CHEBI:choline), p(HGNC:CHRNA7)) hasComponent p(HGNC:CHRNA7) View Subject | View Object

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composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") View Subject | View Object

In α7+ cells, choline application resulted in a calcium signal that peaked at 1050% ΔF/Fθ (±176.4%) in the neurite. Calcium transients in the GC were found to last for ∼1.6 s in both α7 and α7+ cells peaking at 1396% (±154.4%) and 1316% (±146.9%) ΔF/Fθ, relatively (Fig. 4, A and B). PubMed:26088141

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composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") View Subject | View Object

In N2a cells α7345–348A nAChR expression fostered a weak calcium response to (10 mM) choline, whereas expression of α7 nAChRs correlated with noticeable choline-induced calcium transient. Imaging studies in N2a cells expressing α7345–348A nAChRs indicate a significantly lowered calcium signal peak to choline (333.4% ΔF/Fθ ± 35.7%) when compared with N2a cells that express the α7nAChR (peak: 581% ΔF/Fθ ± 122.7%; p = 0.04) (Fig. 4, D and E). PubMed:26088141

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Experimental Factor Ontology (EFO)
Neuro-2a cell

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.