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p(HGNC:CTSB)

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Entity

Name
CTSB
Namespace
HGNC
Namespace Version
20180215
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/hgnc/hgnc-20180215.belns

Appears in Networks 5

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

Inflammasome activation and innate immunity in Alzheimer’s disease v1.0.2

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

In-Edges 3

a(CHEBI:cilostazol) increases p(HGNC:CTSB) View Subject | View Object

Cilostazol (a phosphodiesterase 3 inhibitor) clears Aβ42 from neuronal cell lines by promoting autophagy, upregulating beclin 1, ATG5 and LC3, downregulating mTORC1 and inducing lysosomal cathepsin B; these actions of cilostazol involve activation of SIRT1 as well as upstream Tyr172 phosphorylation of AMPK 108,162,163 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Lysosomes
MeSH
Machado-Joseph Disease

composite(a(CHEBI:"amyloid-beta"), p(HGNC:CTSB)) hasComponent p(HGNC:CTSB) View Subject | View Object

Appears in Networks:

act(a(GO:synapse)) positiveCorrelation p(HGNC:CTSB) View Subject | View Object

Similar therapeutic effects, including restoration of synaptic functions, are seen in APP mouse models after deleting cystatin C (Sun et al. 2008), by overexpressing cathepsin B (Mueller-Steiner et al. 2006), or by enhancing its activity (Butler et al. 2011). PubMed:22908190

Appears in Networks:

Out-Edges 3

p(HGNC:CTSB) increases a(CHEBI:"amyloid-beta") View Subject | View Object

Inhibition of cathepsin B has been found to reduce Abeta production both in vivo and in vitro [92,93] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Neurons

p(HGNC:CTSB) increases deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

However, recent studies suggest that Cathepsin B can degrade Abeta into harmless fragments PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HGNC:CTSB) positiveCorrelation act(a(GO:synapse)) View Subject | View Object

Similar therapeutic effects, including restoration of synaptic functions, are seen in APP mouse models after deleting cystatin C (Sun et al. 2008), by overexpressing cathepsin B (Mueller-Steiner et al. 2006), or by enhancing its activity (Butler et al. 2011). PubMed:22908190

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.