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p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Tau isoform E (412 aa)
Namespace
HBP
Namespace Version
20190207
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/cf4d8bb88754f036b943b4d94ad96e103dcb7149/export/hbp-names.belns

Appears in Networks 1

Caenorhabditis elegans models of tauopathy v1.0.0

In-Edges 1

p(HBP:"Tau isoform E (412 aa)") hasVariant p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) View Subject | View Object

Appears in Networks:

Out-Edges 3

p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) decreases bp(GO:locomotion) View Subject | View Object

Three transgenic lines were generated based on 1N4R wild-type MAPT or its FTD-17 mutant variants P301L and V337M. The mutant lines showed a stronger Unc phenotype than the wild-type tau lines and the severity of the Unc phenotype progressed with age PubMed:29191965

Appears in Networks:

p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) decreases a(MESH:Survival) View Subject | View Object

This worm also shows reduced survival, accumulates detergent-insoluble tau, and undergoes late-onset neurodegeneration (66) PubMed:29191965

Appears in Networks:

p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) increases path(HBP:Neurodegeneration) View Subject | View Object

This worm also shows reduced survival, accumulates detergent-insoluble tau, and undergoes late-onset neurodegeneration (66) PubMed:29191965

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.