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p(HGNC:CHRM5)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
CHRM5
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 4

Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia. v1.0.0

This file encodes the article Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer’s disease and schizophrenia by Choi et al, 2014

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

M1 muscarinic acetylcholine receptor in Alzheimer’s disease v1.0.0

This file encodes the article M1 muscarinic acetylcholine receptor in Alzheimer’s disease by Jiang et al, 2014

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

In-Edges 6

complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) hasComponent p(HGNC:CHRM5) View Subject | View Object

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p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") hasMember p(HGNC:CHRM5) View Subject | View Object

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complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) hasComponent p(HGNC:CHRM5) View Subject | View Object

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a(MESH:"Pars Compacta") association p(HGNC:CHRM5) View Subject | View Object

M5 mAChR is predominantly distributed in the pars compacta of the substantia nigra, a structure that provides dopaminergic innervation to the striatum, and in the ventral tegmental area, a structure providing dopaminergic innervation to the nucleus accumbens and other limbic areas[26, 57]. These areas are well known to play a critical role in the rewarding effects of several drugs of abuse. M5 mAChR-knockout mice are less sensitive to addictive drugs such as morphine and cocaine[58]. PubMed:24590577

Appears in Networks:

complex(p(HGNC:CHRM5), p(HGNC:GNA11)) hasComponent p(HGNC:CHRM5) View Subject | View Object

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p(GFAM:"Cholinergic receptors muscarinic") hasMember p(HGNC:CHRM5) View Subject | View Object

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Out-Edges 4

p(HGNC:CHRM5) association a(MESH:"Pars Compacta") View Subject | View Object

M5 mAChR is predominantly distributed in the pars compacta of the substantia nigra, a structure that provides dopaminergic innervation to the striatum, and in the ventral tegmental area, a structure providing dopaminergic innervation to the nucleus accumbens and other limbic areas[26, 57]. These areas are well known to play a critical role in the rewarding effects of several drugs of abuse. M5 mAChR-knockout mice are less sensitive to addictive drugs such as morphine and cocaine[58]. PubMed:24590577

Appears in Networks:

p(HGNC:CHRM5) increases bp(GO:"response to drug") View Subject | View Object

M5 mAChR is predominantly distributed in the pars compacta of the substantia nigra, a structure that provides dopaminergic innervation to the striatum, and in the ventral tegmental area, a structure providing dopaminergic innervation to the nucleus accumbens and other limbic areas[26, 57]. These areas are well known to play a critical role in the rewarding effects of several drugs of abuse. M5 mAChR-knockout mice are less sensitive to addictive drugs such as morphine and cocaine[58]. PubMed:24590577

Appears in Networks:

p(HGNC:CHRM5) increases act(a(CHEBI:morphine)) View Subject | View Object

M5 mAChR is predominantly distributed in the pars compacta of the substantia nigra, a structure that provides dopaminergic innervation to the striatum, and in the ventral tegmental area, a structure providing dopaminergic innervation to the nucleus accumbens and other limbic areas[26, 57]. These areas are well known to play a critical role in the rewarding effects of several drugs of abuse. M5 mAChR-knockout mice are less sensitive to addictive drugs such as morphine and cocaine[58]. PubMed:24590577

Appears in Networks:

p(HGNC:CHRM5) increases act(a(CHEBI:cocaine)) View Subject | View Object

M5 mAChR is predominantly distributed in the pars compacta of the substantia nigra, a structure that provides dopaminergic innervation to the striatum, and in the ventral tegmental area, a structure providing dopaminergic innervation to the nucleus accumbens and other limbic areas[26, 57]. These areas are well known to play a critical role in the rewarding effects of several drugs of abuse. M5 mAChR-knockout mice are less sensitive to addictive drugs such as morphine and cocaine[58]. PubMed:24590577

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.