a(MESH:"Pars Compacta") association p(HGNC:CHRM5)

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PubMed:24590577

M5 mAChR is predominantly distributed in the pars compacta of the substantia nigra, a structure that provides dopaminergic innervation to the striatum, and in the ventral tegmental area, a structure providing dopaminergic innervation to the nucleus accumbens and other limbic areas[26, 57]. These areas are well known to play a critical role in the rewarding effects of several drugs of abuse. M5 mAChR-knockout mice are less sensitive to addictive drugs such as morphine and cocaine[58].

Related Edges 4

• p(HGNC:CHRM5) association a(MESH:"Pars Compacta")
• p(HGNC:CHRM5) increases bp(GO:"response to drug")
• p(HGNC:CHRM5) increases act(a(CHEBI:morphine))
• p(HGNC:CHRM5) increases act(a(CHEBI:cocaine))

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