complex(p(HGNC:MAPT), p(SFAM:"HSP90 Family"))

Components

• p(HGNC:MAPT)
• p(SFAM:"HSP90 Family")

TAU Interactions Section of NESTOR

This result suggests that the VQIVYK peptide plays a role in the interaction between Hsp90 and tau protein, a hypothesis which is also supported by the fact that a tau variant deleted for the peptide VQIVYK was unable to interact with Hsp90 under immunoprecipitation conditions (Fig. 2B). PubMed:19363271

This result suggests that the VQIVYK peptide plays a role in the interaction between Hsp90 and tau protein, a hypothesis which is also supported by the fact that a tau variant deleted for the peptide VQIVYK was unable to interact with Hsp90 under immunoprecipitation conditions (Fig. 2B). PubMed:19363271

We then investigated what effect over-expression or knockdown of FKBP51 might have on the interaction of tau with other Hsp90 cochaperones that comprise a mature Hsp90 complex. Surprisingly, we found that FKBP51 over-expression decreased the endogenous association of another Hsp90 pro-folding cochaperone, Aha1, with tau despite increasing Hsp90 binding (Fig. 4C). Endogenous p23 binding to tau however was not detected. Conversely, knockdown of FKBP51 with siRNA increased the association of endogenous Aha1 with tau despite decreasing the number of Hsp90 tau complexes. Moreover, endogenous p23 binding to tau was only detectable when FKBP51 was knocked down (Fig. 4C). PubMed:20071522

We then investigated what effect over-expression or knockdown of FKBP51 might have on the interaction of tau with other Hsp90 cochaperones that comprise a mature Hsp90 complex. Surprisingly, we found that FKBP51 over-expression decreased the endogenous association of another Hsp90 pro-folding cochaperone, Aha1, with tau despite increasing Hsp90 binding (Fig. 4C). Endogenous p23 binding to tau however was not detected. Conversely, knockdown of FKBP51 with siRNA increased the association of endogenous Aha1 with tau despite decreasing the number of Hsp90 tau complexes. Moreover, endogenous p23 binding to tau was only detectable when FKBP51 was knocked down (Fig. 4C). PubMed:20071522