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a(HP:"Neurofibrillary tangles")

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Entity

Name
Neurofibrillary tangles
Namespace
HP
Namespace Version
2017-10-05
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/hp/hp-20171108.belns

Appears in Networks 1

Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. v1.0.0

In-Edges 1

a(CHEBI:"lithium atom") decreases a(HP:"Neurofibrillary tangles") View Subject | View Object

and lithium (Shimada et al., 2012) in human tau over-expressing Tg mice induced autophagy, which is accompanied by the reduced levels of pathological tau and NFT formation in tauopathy model mice. PubMed:23528736

Appears in Networks:
Annotations
MeSH
Tauopathies

Out-Edges 1

a(HP:"Neurofibrillary tangles") decreases act(p(FPLX:Proteasome)) View Subject | View Object

PHF-tau isolated from human AD brains in the soluble state was not degraded by the proteasome but instead functioned as an inhibitor of its activity (Keck et al., 2003). PubMed:23528736

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.