a(CHEBI:"quinolinic acid")

Entity

Name

quinolinic acid

Namespace

chebi

Namespace Version

20180906

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

In the normal brain, 70% of KYNA formation is catalyzed by KAT II, one of the three cerebral KATs (199, 200). Systemic treatment of rats and mice with kynurenine leads to an elevation of brain levels of several neuroactive intermediates, including KYNA, the free radical generator 3-hydroxykynurenine, and the excitotoxic quinolinic acid (419). PubMed:19126755

Using PCR arrays, QA significantly induces 10 genes in human neurons known to be associated with AD pathology with 6 belonging to pathways involved in tau phosphorylation and 4 of them in neuroprotection. PubMed:19623258

Using PCR arrays, QA significantly induces 10 genes in human neurons known to be associated with AD pathology with 6 belonging to pathways involved in tau phosphorylation and 4 of them in neuroprotection. PubMed:19623258

Using PCR arrays, QA significantly induces 10 genes in human neurons known to be associated with AD pathology with 6 belonging to pathways involved in tau phosphorylation and 4 of them in neuroprotection. PubMed:19623258

Using PCR arrays, QA significantly induces 10 genes in human neurons known to be associated with AD pathology with 6 belonging to pathways involved in tau phosphorylation and 4 of them in neuroprotection. PubMed:19623258

Using PCR arrays, QA significantly induces 10 genes in human neurons known to be associated with AD pathology with 6 belonging to pathways involved in tau phosphorylation and 4 of them in neuroprotection. PubMed:19623258

Kynurenic pathway is overactive in AD. QA is co-localized with hyperphosphorylated tau within cortical neurons in AD brain. In primary cultures of human neurons, QA treatment increased tau phosphorylation at serine 199/202, threonine 231 and serine 396/404 in a dose dependent manner. This increase in tau phosphorylation was paralleled by a substantial decrease in the total protein phosphatase activity, mostly in PP2A expression and modest in PP1. PubMed:19623258

Kynurenic pathway is overactive in AD. QA is co-localized with hyperphosphorylated tau within cortical neurons in AD brain. In primary cultures of human neurons, QA treatment increased tau phosphorylation at serine 199/202, threonine 231 and serine 396/404 in a dose dependent manner. This increase in tau phosphorylation was paralleled by a substantial decrease in the total protein phosphatase activity, mostly in PP2A expression and modest in PP1. PubMed:19623258

Kynurenic pathway is overactive in AD. QA is co-localized with hyperphosphorylated tau within cortical neurons in AD brain. In primary cultures of human neurons, QA treatment increased tau phosphorylation at serine 199/202, threonine 231 and serine 396/404 in a dose dependent manner. This increase in tau phosphorylation was paralleled by a substantial decrease in the total protein phosphatase activity, mostly in PP2A expression and modest in PP1. PubMed:19623258

Using PCR arrays, QA significantly induces 10 genes in human neurons known to be associated with AD pathology with 6 belonging to pathways involved in tau phosphorylation and 4 of them in neuroprotection. PubMed:19623258

Using PCR arrays, QA significantly induces 10 genes in human neurons known to be associated with AD pathology with 6 belonging to pathways involved in tau phosphorylation and 4 of them in neuroprotection. PubMed:19623258

Using PCR arrays, QA significantly induces 10 genes in human neurons known to be associated with AD pathology with 6 belonging to pathways involved in tau phosphorylation and 4 of them in neuroprotection. PubMed:19623258

Using PCR arrays, QA significantly induces 10 genes in human neurons known to be associated with AD pathology with 6 belonging to pathways involved in tau phosphorylation and 4 of them in neuroprotection. PubMed:19623258

Using PCR arrays, QA significantly induces 10 genes in human neurons known to be associated with AD pathology with 6 belonging to pathways involved in tau phosphorylation and 4 of them in neuroprotection. PubMed:19623258

Nicotinic acid is synthesized from quinolinic acid through pyridine nucleotide cycle, and is controlled by quinolinate phosphoribosyltransferase (QPRT) PubMed:19165623