a(CHEBI:"quinolinic acid") decreases p(HGNC:PPP2CA)

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PubMed:19623258

Kynurenic pathway is overactive in AD. QA is co-localized with hyperphosphorylated tau within cortical neurons in AD brain. In primary cultures of human neurons, QA treatment increased tau phosphorylation at serine 199/202, threonine 231 and serine 396/404 in a dose dependent manner. This increase in tau phosphorylation was paralleled by a substantial decrease in the total protein phosphatase activity, mostly in PP2A expression and modest in PP1.

Related Edges 2

• a(CHEBI:"quinolinic acid") decreases p(HGNC:PPP1CA)
• a(CHEBI:"quinolinic acid") directlyIncreases act(complex(GO:"NMDA selective glutamate receptor complex"))

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