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r(HGNC:"BACE1-AS")

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Entity

Name
BACE1-AS
Namespace
hgnc
Namespace Version
20190224
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/efc856fb009a39e4d284269a6801f79ed3d3cf56/external/hgnc-names.belns

Appears in Networks 2

New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases v1.0.0

Upstream regulators and downstream effectors of NF-κBinAlzheimer's disease v1.0.0

In-Edges 2

path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:"BACE1-AS") View Subject | View Object

BACE1‐AS is transcribed by opposite strand BACE1. Its upregulation in patients with Alzheimer’s can be used as a new biomarker for the diagnosis of this disease. PubMed:30663117

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:"BACE1-AS") View Subject | View Object

Upon exposure to various cell stressors including Aβ 42 , expression of BACE1-AS becomes elevated, increasing BACE1 mRNA stability and generating additional Aβ 42 through a post-transcriptional feed-forward mechanism [74]. PubMed:27288790

Appears in Networks:

Out-Edges 9

r(HGNC:"BACE1-AS") biomarkerFor path(MESH:"Alzheimer Disease") View Subject | View Object

BACE1‐AS is transcribed by opposite strand BACE1. Its upregulation in patients with Alzheimer’s can be used as a new biomarker for the diagnosis of this disease. PubMed:30663117

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

r(HGNC:"BACE1-AS") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

BACE1‐AS is transcribed by opposite strand BACE1. Its upregulation in patients with Alzheimer’s can be used as a new biomarker for the diagnosis of this disease. PubMed:30663117

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

r(HGNC:"BACE1-AS") increases r(HGNC:BACE1) View Subject | View Object

BACE1‐AS can increase the expression of BACE1 mRNA by increasing its stability, which gives rise to AD PubMed:30663117

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

r(HGNC:"BACE1-AS") increases a(CHEBI:"amyloid-beta") View Subject | View Object

It has been reported that downregulation of BACE1‐AS reduces the amount of β‐ameloid and plaques PubMed:30663117

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

r(HGNC:"BACE1-AS") increases path(MESH:"Plaque, Amyloid") View Subject | View Object

It has been reported that downregulation of BACE1‐AS reduces the amount of β‐ameloid and plaques PubMed:30663117

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

r(HGNC:"BACE1-AS") regulates r(HGNC:BACE1) View Subject | View Object

BACE1-AS regulates BACE1 mRNA and subsequently BACE1 protein expression in vitro and in vivo. PubMed:27288790

Appears in Networks:

r(HGNC:"BACE1-AS") decreases deg(r(HGNC:BACE1)) View Subject | View Object

Upon exposure to various cell stressors including Aβ 42 , expression of BACE1-AS becomes elevated, increasing BACE1 mRNA stability and generating additional Aβ 42 through a post-transcriptional feed-forward mechanism [74]. PubMed:27288790

Appears in Networks:

r(HGNC:"BACE1-AS") regulates p(HGNC:BACE1) View Subject | View Object

BACE1-AS regulates BACE1 mRNA and subsequently BACE1 protein expression in vitro and in vivo. PubMed:27288790

Appears in Networks:

r(HGNC:"BACE1-AS") increases a(CHEBI:"amyloid-beta polypeptide 42") View Subject | View Object

Upon exposure to various cell stressors including Aβ 42 , expression of BACE1-AS becomes elevated, increasing BACE1 mRNA stability and generating additional Aβ 42 through a post-transcriptional feed-forward mechanism [74]. PubMed:27288790

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.