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p(MGI:Ifng)

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Entity

Name
Ifng
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 2

Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine v1.0.0

Tau protein aggregation is associated with cellular senescence in the brain v1.0.0

In-Edges 5

a(CHEBI:Anatabine) causesNoChange p(MGI:Ifng) View Subject | View Object

However, anatabine significantly suppressed the production of IL-1b, IL-6 and IL-17A in the serum of EAE mice (Fig. 2B) but did not significantly impact IFN-gamma and TNF-alpha PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum
MeSH
Encephalomyelitis

a(CHEBI:Anatabine) decreases p(MGI:Ifng) View Subject | View Object

Anatabine appears to fully suppress IL-1b, INF-gamma and TNF-a elevation in the spleen of EAE mice (Fig. 2C). PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spleen
MeSH
Encephalomyelitis

path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Ifng) View Subject | View Object

We found that IL-1b, IFN-gamma, TNF-alpha, IL-6 and IL-17A were significantly elevated in the serum of EAE mice compared to control non-immunized mice PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum

path(MESH:Encephalomyelitis) increases p(MGI:Ifng) View Subject | View Object

A significant elevation of IL-1b, INF-gamma and TNF-alpha was observed in the spleen of EAE mice compared to control non immunized animals PubMed:23383175

Appears in Networks:
Annotations
MeSH
Spleen

a(GO:"neurofibrillary tangle") increases act(p(MGI:Ifng)) View Subject | View Object

Consistent with NFTs from human AD, mouse NFTs also caused significant activation scores for IFNG, TNF, IL-1B, as well as enrichment in other senescence associated JAK, STAT, CDKN2A and BCL2 predicted upstream regulators (Figure 1c) indicating translational relevance for using tauNFT mice to explore our hypothesis PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease

Out-Edges 1

p(MGI:Ifng) positiveCorrelation path(MESH:Encephalomyelitis) View Subject | View Object

We found that IL-1b, IFN-gamma, TNF-alpha, IL-6 and IL-17A were significantly elevated in the serum of EAE mice compared to control non-immunized mice PubMed:23383175

Appears in Networks:
Annotations
MeSH
Serum

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.