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complex(a(CHEBI:Nilvadipine), p(HGNC:SYK))

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Components

Appears in Networks 1

The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

In-Edges 2

a(CHEBI:Nilvadipine) increases complex(a(CHEBI:Nilvadipine), p(HGNC:SYK)) View Subject | View Object

To ensure that the reduction in Syk activity observed was not due to an interaction of the peptide substrate with (-)-nilvadipine, we also verified that (-)-nilvadipine was able to directly bind to Syk. PubMed:25331948

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a(CHEBI:Nilvadipine) increases complex(a(CHEBI:Nilvadipine), p(HGNC:SYK)) View Subject | View Object

We measured the binding affinity of (-)-nilvadipine for Syk using biolayer interferometry and confirmed that (-)-nilvadipine binds to human recombinant Syk with a binding dissociation constant (KD) of 2.1 µM (Fig. 5C), further suggesting that Syk is the possible target impacted by nilvadipine. PubMed:25331948

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Out-Edges 2

complex(a(CHEBI:Nilvadipine), p(HGNC:SYK)) hasComponent p(HGNC:SYK) View Subject | View Object

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complex(a(CHEBI:Nilvadipine), p(HGNC:SYK)) hasComponent a(CHEBI:Nilvadipine) View Subject | View Object

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.