Appears in Networks 1

Provenance

PubMed:25331948

We measured the binding affinity of (-)-nilvadipine for Syk using biolayer interferometry and confirmed that (-)-nilvadipine binds to human recombinant Syk with a binding dissociation constant (KD) of 2.1 µM (Fig. 5C), further suggesting that Syk is the possible target impacted by nilvadipine.

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.