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  3. rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081)))

rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081)))

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Appears in Networks 1

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

In-Edges 2

p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081))) View Subject | View Object

In the amyloidogenic pathway, APP is primarily processed by beta-secretase at the first residue or at the 11th residue (so called beta’ site) of the Abeta peptide sequence (Fig. 1), shedding sAPPbeta and generating a membrane associated C-terminal fragment consisting of 99 amino acids (C99) (Sarah and Robert 2007) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081))) View Subject | View Object

Abeta generation is initiated by beta-cleavage at the ectodomain of APP, resulting in the generation of an sAPP-beta domain and the membrane associated APP C-terminal fragment C99. The putative beta-secretase, beta-site APP cleaving enzyme 1 (BACE1), was first identified and characterized in 1999 (Sinha et al. 1999; Vassar et al. 1999; Yan et al. 1999; Hussain et al. 2000; Lin et al. 2000). PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

Out-Edges 3

rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081))) hasReactant p(HGNC:APP) View Subject | View Object

Appears in Networks:

rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081))) hasProduct a(HBP:HBP00042) View Subject | View Object

Appears in Networks:

rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081))) hasProduct a(HBP:HBP00081) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.