D058225

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Entity

Name: D058225
Namespace: mesh
Namespace Version: 20180828
Namespace URL: https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/mesh.belns

Appears in Networks 2

Interplay of neurotransmitters in Alzheimer's disease v1.0.0

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

In-Edges 3

path(MESH:D000544) association path(MESH:D058225) View Subject | View Object

From the perspective of brain histopathology, Alzheimer's disease has three characteristic features—the appearance of beta-amyloid plaques, the presence of neurofibrillary tangles, and the loss of neuronal cells PubMed:16273023

Appears in Networks:

Interplay of neurotransmitters in Alzheimer's disease v1.0.0

Annotations

Disease Ontology (DO): Alzheimer's disease

p(HGNC:ACHE) association path(MESH:D058225) View Subject | View Object

In this regard, AChE has been localized to SPs in the vicinity of cholinergic synapses, and experimental evidence suggests that AChE promotes Ab fibrillization [164], suggesting that a further benefit from AChE inhibitor therapy may be to prevent continued Ab deposition in cholinergic projection sites. PubMed:18986241

Appears in Networks:

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

Annotations

MeSH: Cognitive Dysfunction

p(HGNC:BCHE) association path(MESH:D058225) View Subject | View Object

Butyrylcholinesterase (BChE) is a serine hydrolase similar to AChE that is widely distributed throughout the CNS and also catalyzes the hydrolysis of ACh. BChE is localized to neurons and glia, and is associated with NFTs and senile plaques (SPs) in AD brain [32]. Interestingly, population-based genetic studies of AD have identified a point mutation that changes Ala539 to threonine in the K variant of BChE, which effectively reduces serum BChE concentrations, and may be associated with cognitive decline [33]. BChE activity also increases in AD brain whereas AChE activity remains unchanged or declines [34,35]. PubMed:18986241