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complex(a(CHEBI:heme), p(MGI:Tlr4))

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Components

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 1

path(MESH:Inflammation) positiveCorrelation complex(a(CHEBI:heme), p(MGI:Tlr4)) View Subject | View Object

In that study, heme was shown to specifically bind to endothelial Toll-like receptors (TLR4) and trigger a cascade of inflammatory responses, which could be attributed to oxidation and degradation of cell-free Hb [73]. PubMed:24486321

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Discussion

Out-Edges 3

complex(a(CHEBI:heme), p(MGI:Tlr4)) hasComponent a(CHEBI:heme) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:heme), p(MGI:Tlr4)) hasComponent p(MGI:Tlr4) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:heme), p(MGI:Tlr4)) positiveCorrelation path(MESH:Inflammation) View Subject | View Object

In that study, heme was shown to specifically bind to endothelial Toll-like receptors (TLR4) and trigger a cascade of inflammatory responses, which could be attributed to oxidation and degradation of cell-free Hb [73]. PubMed:24486321

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Discussion

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.