p(HGNC:SNCAIP, pmod(Ub))

Entity

Name

SNCAIP

Namespace

hgnc

Namespace Version

20180906

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Parkin also ubiquitinates Synphilin-1, a protein of hitherto unknown function that contains a coiled-coiled domain and an ATP/GTP binding motif and that associates with alphaSYN (Chung et al., 2001). PubMed:14556719

Since inclusion bodies are lacking in most cases of AR-JP, it is possible that the ubiquitination of Synphilin by wildtype Parkin plays a role in their formation, by targeting ubiquitinated Synphilin to these bodies and removing it from the cytosol where it can be toxic PubMed:14556719

Since inclusion bodies are lacking in most cases of AR-JP, it is possible that the ubiquitination of Synphilin by wildtype Parkin plays a role in their formation, by targeting ubiquitinated Synphilin to these bodies and removing it from the cytosol where it can be toxic PubMed:14556719

Instead, impairment of alphaSYN function may disturb ubiquitination of alphaSYN-associated proteins, such as Synphilin (Chung et al., 2001) and tyrosine hydroxylase (Doskeland and Flatmark, 2002), and thereby perturb neuronal homeostasis PubMed:14556719